abstract：:Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor family whose expression and activities are restricted to a limited number of organs including the liver and gastrointestinal tract. In this review, we present robust evidence pointing to HNF4 as a master regulator of ce...

journal_title：Cells

authors： Dubois V,Staels B,Lefebvre P,Verzi MP,Eeckhoute J

更新日期：2020-09-28 00:00:00

abstract：:Recent studies have revealed synaptic dysfunction to be a hallmark of various psychiatric diseases, and that glial cells participate in synapse formation, development, and plasticity. Glial cells contribute to neuroinflammation and synaptic homeostasis, the latter being essential for maintaining the physiological func...

journal_title：Cells

authors： Kim YS,Choi J,Yoon BE

更新日期：2020-09-27 00:00:00

abstract：:Astrocytes are essential players in brain circuit development and homeostasis, controlling many aspects of synapse formation, function, plasticity and elimination both during development and adulthood. Accordingly, alterations in astrocyte morphogenesis and physiology may severely affect proper brain development, caus...

journal_title：Cells

authors： Fossati G,Matteoli M,Menna E

更新日期：2020-09-26 00:00:00

abstract：:The authors wish to make the following corrections to this paper [...]. ...

journal_title：Cells

authors： Nemade H,Acharya A,Chaudhari U,Nembo E,Nguemo F,Riet N,Abken H,Hescheler J,Papadopoulos S,Sachinidis A

更新日期：2020-09-24 00:00:00

abstract：:The experimental determination of the relative biological effectiveness of thermal neutron factors is fundamental in Boron Neutron Capture Therapy. The present values have been obtained while using mixed beams that consist of both neutrons and photons of various energies. A common weighting factor has been used for bo...

journal_title：Cells

authors： Pedrosa-Rivera M,Praena J,Porras I,Sabariego MP,Köster U,Haertlein M,Forsyth VT,Ramírez JC,Jover C,Jimena D,Osorio JL,Álvarez P,Ruiz-Ruiz C,Ruiz-Magaña MJ

更新日期：2020-09-23 00:00:00

abstract：:Aging is associated with metabolic changes and low-grade inflammation in several organs, which may be due to NLRP3 inflammasome activation. Methods: Here, we asked whether age-related liver changes such as lipid metabolism and fibrosis are reduced in aged mice lacking the NLRP3 inflammasome. We report reduced protein ...

journal_title：Cells

authors： Gallego P,Castejón-Vega B,Del Campo JA,Cordero MD

更新日期：2020-09-23 00:00:00

abstract：:Human mesenchymal stromal/stem cells (hMSCs) show great promise in cell therapy due to their immunomodulatory properties. The overall immunomodulatory response of hMSCs resembles the resolution of inflammation, in which lipid mediators and regulatory macrophages (Mregs) play key roles. We investigated the effect of hM...

journal_title：Cells

authors： Holopainen M,Impola U,Lehenkari P,Laitinen S,Kerkelä E

更新日期：2020-09-22 00:00:00

abstract：:Peripheral nerve injuries result in the loss of the motor, sensory and autonomic functions of the denervated segments of the body. Neurons can regenerate after peripheral axotomy, but inaccuracy in reinnervation causes a permanent loss of function that impairs complete recovery. Thus, understanding how regenerating ax...

journal_title：Cells

authors： Bolívar S,Navarro X,Udina E

更新日期：2020-09-20 00:00:00

abstract：:The Epithelial Cell Adhesion Molecule or EpCAM is a well-known marker highly expressed in carcinomas and showing a strong correlation with poor cancer prognosis. While its name relates to its proposed function as a cell adhesion molecule, EpCAM has been shown to have various signalling functions. In particular, it has...

journal_title：Cells

authors： Fagotto F

更新日期：2020-09-19 00:00:00

abstract：:Apoptosis, a form of programmed cell death, is a highly regulated process critical for tissue development, homeostasis, and pathogenesis of various diseases [...]. ...

journal_title：Cells

authors： Ladokhin AS

更新日期：2020-09-18 00:00:00

abstract：:To investigate the role of PR isoforms on the homeostasis of stem cells in the normal and neoplastic mammary gland, we used PRA and PRB transgenic mice and the T47D human breast cancer cell line and its derivatives, T47D YA and YB (manipulated to express only PRA or PRB, respectively). Flow cytometry and mammosphere a...

journal_title：Cells

authors： Recouvreux MS,Diaz Bessone MI,Taruselli A,Todaro L,Lago Huvelle MA,Sampayo RG,Bissell MJ,Simian M

更新日期：2020-09-11 00:00:00

abstract：BACKGROUND:Regenerative therapies based on autologous mesenchymal stem cells (MSC) as well as stem cells in general are still facing an unmet need for non-invasive sampling, availability, and scalability. The only known adult source of autologous MSCs permanently available with no pain, discomfort, or infection risk is...

journal_title：Cells

authors： Li H,Masieri FF,Schneider M,Kottek T,Hahnel S,Yamauchi K,Obradović D,Seon JK,Yun SJ,Ferrer RA,Franz S,Simon JC,Lethaus B,Savković V

更新日期：2020-09-10 00:00:00

abstract：:Background: In retinitis pigmentosa (RP), inherited rod death is followed by cone loss and blindness. Why cones die is still a matter of consideration. Here, we investigate the pathogenic role of the sympathetic transmission in the rd10 mouse model of RP. Methods: Retinal levels of beta adrenergic receptor (BAR) 2 and...

journal_title：Cells

authors： Cammalleri M,Dal Monte M,Amato R,Lapi D,Bagnoli P

更新日期：2020-09-09 00:00:00

abstract：:Tendons are vital to joint movement by connecting muscles to bones. Along with an increasing incidence of tendon injuries, tendon disorders can burden the quality of life of patients or the career of athletes. Current treatments involve surgical reconstruction and conservative therapy. Especially in the elderly popula...

journal_title：Cells

authors： Chu J,Lu M,Pfeifer CG,Alt V,Docheva D

更新日期：2020-09-08 00:00:00

abstract：:Increasing evidence suggests that metabolic alterations may be etiologically linked to neurodegenerative disorders such as Parkinson's disease (PD) and in particular empathizes the possibility of targeting mitochondrial dysfunctions to improve PD progression. Under different pathological conditions (i.e., cardiac and ...

journal_title：Cells

authors： Piccirillo S,Magi S,Preziuso A,Castaldo P,Amoroso S,Lariccia V

更新日期：2020-09-06 00:00:00

abstract：:Many cells rearrange proteins and other components into spatially distinct domains in a process called polarization. This asymmetric patterning is required for a number of biological processes including asymmetric division, cell migration, and embryonic development. Proteins involved in polarization are highly conserv...

journal_title：Cells

authors： Seirin-Lee S,Gaffney EA,Dawes AT

更新日期：2020-09-05 00:00:00

abstract：:Cancer cells perform a metabolic rewiring to sustain an increased growth rate and compensate for the redox stress caused by augmented energy metabolism. The metabolic changes are not the same in all cancers. Some features, however, are considered hallmarks of this disease. As an example, all cancer cells rewire the am...

journal_title：Cells

authors： Scalise M,Console L,Rovella F,Galluccio M,Pochini L,Indiveri C

更新日期：2020-09-03 00:00:00

abstract：:We have previously shown that the combination of radiotherapy with human umbilical-cord-derived mesenchymal stromal/stem cells (MSCs) cell therapy significantly reduces the size of the xenotumors in mice, both in the directly irradiated tumor and in the distant nonirradiated tumor or its metastasis. We have also shown...

journal_title：Cells

authors： Tovar I,Guerrero R,López-Peñalver JJ,Expósito J,Ruiz de Almodóvar JM

更新日期：2020-09-02 00:00:00

abstract：:The 70 kDa heat shock protein (HSP70) is a stress-inducible protein that has been shown to protect the brain from various nervous system injuries. It allows cells to withstand potentially lethal insults through its chaperone functions. Its chaperone properties can assist in protein folding and prevent protein aggregat...

journal_title：Cells

authors： Kim JY,Barua S,Huang MY,Park J,Yenari MA,Lee JE

更新日期：2020-09-02 00:00:00

abstract：:Cathepsin S (CatS) is a secreted cysteine protease that cleaves certain extracellular matrix proteins, regulates antigen presentation in antigen-presenting cells (APC), and promotes M2-type macrophage and dendritic cell polarization. CatS is overexpressed in many solid cancers, and overall, it appears to promote an im...

journal_title：Cells

authors： Fuchs N,Meta M,Schuppan D,Nuhn L,Schirmeister T

更新日期：2020-09-02 00:00:00

abstract：:Actin and non-muscle myosins have long been known to play important roles in growth cone steering and neurite outgrowth. More recently, novel functions for non-muscle myosin have been described in axons and dendritic spines. Consequently, possible roles of actomyosin contraction in organizing and maintaining structura...

journal_title：Cells

authors： Mikhaylova M,Rentsch J,Ewers H

更新日期：2020-09-01 00:00:00

abstract：:Preeclampsia (PE) is a pregnancy-specific disorder associated with hypertension and proteinuria. Since there is no proven method to treat PE, early prediction and accurate diagnosis are essential for appropriate management of the disease. Thus, reliable biomarkers for diagnosing PE need to be identified and evaluated....

journal_title：Cells

authors： Kim S,Park M,Kim JY,Kim T,Hwang JY,Ha KS,Won MH,Ryoo S,Kwon YG,Kim YM

更新日期：2020-08-31 00:00:00

abstract：:The ongoing threat of viral infections and the emergence of antiviral drug resistance warrants a ceaseless search for new antiviral compounds. Broadly-inhibiting compounds that act on elements shared by many viruses are promising antiviral candidates. Here, we identify a peptide derived from the cowpox virus protein C...

journal_title：Cells

authors： Luteijn RD,Praest P,Thiele F,Sadasivam SM,Singethan K,Drijfhout JW,Bach C,de Boer SM,Lebbink RJ,Tao S,Helfer M,Bach NC,Protzer U,Costa AI,Killian JA,Drexler I,Wiertz EJHJ

更新日期：2020-08-29 00:00:00

abstract：:Lamins are important filaments forming the inner nuclear membrane. Lamin A is processed by zinc metalloproteinase (ZMPSTE24). Failure to cleave a truncated form of prelamin A-also called progerin-causes Hutchinson-Gilford progeria syndrome a well-known premature aging disease. Minor levels of progerin are readily expr...

journal_title：Cells

authors： Messner M,Ghadge SK,Maurer T,Graber M,Staggl S,Christine Maier S,Pölzl G,Zaruba MM

更新日期：2020-08-28 00:00:00

abstract：:Fear is a fundamental evolutionary process for survival. However, excess or irrational fear hampers normal activity and leads to phobia. The amygdala is the primary brain region associated with fear learning and conditioning. There, Rho GTPases are molecular switches that act as signaling molecules for further downstr...

journal_title：Cells

authors： Sarowar T,Grabrucker AM

更新日期：2020-08-26 00:00:00

abstract：:An outbreak of the novel coronavirus (CoV) SARS-CoV-2, the causative agent of COVID-19 respiratory disease, infected millions of people since the end of 2019, led to high-level morbidity and mortality and caused worldwide social and economic disruption. There are currently no antiviral drugs available with proven effi...

journal_title：Cells

authors： Aslam M,Ladilov Y

更新日期：2020-08-25 00:00:00

abstract：:In the last decade, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) in in vivo imaging has attempted to demonstrate the presence of neuroinflammatory reactions by measuring the 18 kDa translocator protein (TSPO) expression in many diseases of the central nervous system. We foc...

journal_title：Cells

authors： Tournier BB,Tsartsalis S,Ceyzériat K,Garibotto V,Millet P

更新日期：2020-08-21 00:00:00

abstract：:Growth factors are important regulators during organ development. For many vertebrates (but not humans) it is known how they contribute to the formation and expansion of PDX1-positive cells during pancreas organogenesis. Here, the effects of the fibroblast growth factors FGF2, FGF7, FGF10, and epidermal growth factor ...

journal_title：Cells

authors： Dettmer R,Cirksena K,Münchhoff J,Kresse J,Diekmann U,Niwolik I,Buettner FFR,Naujok O

更新日期：2020-08-20 00:00:00

abstract：:The endoplasmic reticulum (ER) stress response and autophagy are important cellular responses that determine cell fate and whose dysregulation is implicated in the perturbation of homeostasis and diseases. Tonicity-responsive enhancer-binding protein (TonEBP, also called NFAT5) is a pleiotropic stress protein that med...

journal_title：Cells

authors： Kang HJ,Yoo EJ,Lee HH,An SM,Park H,Lee-Kwon W,Choi SY,Kwon HM

更新日期：2020-08-20 00:00:00

abstract：:Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair requires the membrane protein dysferlin. We previously identified that, similar to dysferlin deficit, lack of annexin A2 (AnxA2) also impairs repair of skeletal myofibers. Here, we have studied the mechanism of AnxA2-mediated musc...

journal_title：Cells

authors： Bittel DC,Chandra G,Tirunagri LMS,Deora AB,Medikayala S,Scheffer L,Defour A,Jaiswal JK

更新日期：2020-08-19 00:00:00

abstract：:Glioblastoma multiforme is one of the most malignant types of cancer. This is mainly due to a cell subpopulation with an extremely aggressive potential, called glioblastoma stem-like cells (GSCs). These cells produce high levels of extracellular adenosine which has been associated with increased chemoresistance, migra...

journal_title：Cells

authors： Alarcón S,Toro MLÁ,Villarreal C,Melo R,Fernández R,Ayuso Sacido A,Uribe D,San Martín R,Quezada C

更新日期：2020-08-18 00:00:00

abstract：:Blood-derived microRNA signatures have emerged as powerful biomarkers for predicting and diagnosing cardiovascular disease, cancer, and metabolic disorders. Platelets and platelet-derived microvesicles are a major source of microRNAs. We have previously shown that the inappropriate anticoagulation and storage of blood...

journal_title：Cells

authors： Mussbacher M,Krammer TL,Heber S,Schrottmaier WC,Zeibig S,Holthoff HP,Pereyra D,Starlinger P,Hackl M,Assinger A

更新日期：2020-08-18 00:00:00

abstract：BACKGROUND:The current approaches to distinguish follicular adenomas (FA) and follicular thyroid cancer (FTC) at the pre-operative stage have low predictive value. Liquid biopsy-based analysis of circulating extracellular vesicles (EVs) presents a promising diagnostic method. However, the extreme heterogeneity of plasm...

journal_title：Cells

authors： Zabegina L,Nazarova I,Knyazeva M,Nikiforova N,Slyusarenko M,Titov S,Vasilyev D,Sleptsov I,Malek A

更新日期：2020-08-18 00:00:00

abstract：:The nuclear envelope (NE) consists of the inner and outer nuclear membranes (INM and ONM), and the nuclear pore complex (NPC), which penetrates the double membrane. ONM continues with the endoplasmic reticulum (ER). INM and NPC can interact with chromatin to regulate the genetic activities of the chromosome. Studies i...

journal_title：Cells

authors： Hirano Y,Asakawa H,Sakuno T,Haraguchi T,Hiraoka Y

更新日期：2020-08-16 00:00:00

abstract：:Infectious endocarditis (IE) remains one of the deadliest heart diseases with a high death rate, generally following thrombo-embolic events. Today, therapy is based on surgery and antibiotic therapy. When thromboembolic complications in IE patients persist, this is often due to our lack of knowledge regarding the path...

journal_title：Cells

authors： Hannachi N,Lepidi H,Fontanini A,Takakura T,Bou-Khalil J,Gouriet F,Habib G,Raoult D,Camoin-Jau L,Baudoin JP

更新日期：2020-08-13 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in adult tissues, being involved in growth, differentiation, maintenance and repair of various tissues and organs. The role of EGFR in the regulation ...

journal_title：Cells

authors： Romano R,Bucci C

更新日期：2020-08-12 00:00:00

abstract：:Several decades after its discovery, the hepatitis B virus (HBV) still displays one of the most successful pathogens in human populations worldwide. The identification and characterization of interactions between cellular and pathogenic components are essential for the development of antiviral treatments. Due to its s...

journal_title：Cells

authors： Zeyen L,Döring T,Prange R

更新日期：2020-08-12 00:00:00

abstract：:More than 50 years after the first description of Bronchopulmonary dysplasia (BPD) by Northway, this chronic lung disease affecting many preterm infants is still poorly understood. Additonally, approximately 40% of preterm infants suffering from severe BPD also suffer from Bronchopulmonary dysplasia-associated pulmona...

journal_title：Cells

authors： Chao CM,Chong L,Chu X,Shrestha A,Behnke J,Ehrhardt H,Zhang J,Chen C,Bellusci S

更新日期：2020-08-11 00:00:00

abstract：:The calcium (Ca2+)-dependent membrane-binding Annexin A6 (AnxA6), is a multifunctional, predominantly intracellular scaffolding protein, now known to play relevant roles in different cancer types through diverse, often cell-type-specific mechanisms. AnxA6 is differentially expressed in various stages/subtypes of sever...

journal_title：Cells

authors： Korolkova OY,Widatalla SE,Williams SD,Whalen DS,Beasley HK,Ochieng J,Grewal T,Sakwe AM

更新日期：2020-08-07 00:00:00

abstract：:TROP1 (EpCAM) and TROP2 are homologous cell surface proteins that are widely expressed, and often co-expressed, in developing and adult epithelia. Various functions have been ascribed to EpCAM and TROP2, but responsible mechanisms are incompletely characterized and functional equivalence has not been examined. Adult i...

journal_title：Cells

authors： Nakato G,Morimura S,Lu M,Feng X,Wu C,Udey MC

更新日期：2020-08-06 00:00:00